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            臨床PI
            吳炅 教授
            教授,博士生導師
            E-mail: wujiong1122@vip.sina.com
             

              1993年與1998年分別獲復旦大學上海醫學院 (原上海醫科大學) 醫學學士學位和腫瘤學博士學位。1998年獲UICC ICRETT資助赴美國加州大學洛杉磯分校,研究乳腺肌上皮細胞旁分泌對乳腺癌生長與浸潤的作用。2004年7月赴美國Texas, Houston, M.D. Anderson腫瘤中心整形外科進修一期乳房重建手術。2008年起任復旦大學腫瘤醫院乳腺外科主任醫師,現任復旦大學附屬腫瘤醫院業務副院長,中國抗癌協會乳腺癌專業委員會候任主任委員,上海市醫學會腫瘤靶分子專科分會主任委員,教授,博士生導師。2004年以第三完成人獲國家科技進步二等獎(乳腺癌的臨床和基礎研究),作為第三完成人于2002年和2003年2次獲得上海市科技進步二等獎;作為主要參與者2次獲得上海市科技進步三等獎;先后獲上海市衛生局首批"醫苑新星"、上海市衛生局先進工作者、復旦大學"世紀之星"、上海市科技啟明星、上海市教委曙光計劃等人才基金資助。在國內外刊物上共發表論文200余篇,以第一作者及通訊作者身份發表SCI論文70余篇。參與撰寫《現代乳腺腫瘤學進展》(2002年)、《乳腺腫瘤學》(2005年)等。目前正承擔國家重大慢病非傳染性疾病防控研究課題、上海市科委優秀學術帶頭人計劃、國家自然科學基金面上項目等研究。


            研究領域:

              致力于開展基因標志物在乳腺癌早期診斷、預后及療效預測中的價值等基礎研究;積極應用、推廣新的外科技術,諸如前哨淋巴結活檢、乳房重建手術,豐富及完善腫瘤-整復領域臨床研究。


            研究團隊:

              研究助理:遲亞云、薛靜彥               博后:李倫

              研究生:   王嘉、侯劍晶、桑雨廷、周旭婕、季瑋儒、李培、吳芷菀、張琪、陳銘、吳可、邵鼎軼、李寒露、馬雨薇、鄭舒月


            代表性論著:

            1. Li L, Su Y, Xiu B, Huang X, Chi W, Hou J, Zhang Y, Tian J, Wang J, Wu J*. Comparison of prepectoral and subpectoral breast reconstruction after mastectomies: A systematic review and meta analysis. Eur J Surg Oncol, 2019 Sep; 45(9):1542-1550.
            2. Rong Guo, Lun Li, Yonghui Su, Bingqiu Xiu, Qi Zhang, Jia Wang, Weiru Chi, Benlong Yang, Yingying Zhang, Ayong Cao, Zhimin Shao, Jiong Wu*. Current practice and barriers of mesh-assisted implant-based breast reconstruction in China: A nationwide cross-sectional survey of 110 hospitals. Eur J Surg Oncol, 2019 Sep.
            3. Yayun Chi#, Jingyan Xue#, Sheng Huang#, Bingqiu Xiu#, Yonghui Su, Wei Wang, Rong Guo, Lei Wang, Lun Li, Zhiming Shao, Wei Jin, Zhaohui Wu*, Jiong Wu*. CapG promotes resistance to paclitaxel in breast cancer through transactivation of PIK3R1/P50. Theranostics,   doi:10.7150/thno.36338.
            4. Sheng Huang#, Yayun Chi#, Yi Qin#, Ziliang Wang, Bingqiu Xiu, Yonghui Su, Rong Guo, Liang Guo, Hefen Sun, Chujia Zeng, Shuling Zhou, Xin Hu, Sheng Liu, Zhimin Shao, Zhaohui Wu, Wei Jin, Jiong Wu*. CAPG enhances breast cancer metastasis by competing with PRMT5 to modulate STC-1 transcription. Theranostics, 2018; 8(9): 2549-2564.
            5. Guo L, Chi Y, Xue J, Ma L, Shao Z, Wu J*. Phosphorylated eIF2α predicts disease-free survival in triple-negative breast cancer patients. Sci Rep, 2017; 7:44674.
            6. Huang NS, Quan CL, Mo M, Chen JJ, Yang BL, Huang XY, Wu J*. A prospective study of breast anthropomorphic measurements, volume and ptosis in 605 Asian patients with breast cancer or benign breast disease. PLoS One, 2017; 12(2):e0172122.
            7. Xue J#, Chi Y#, Chen Y, Huang S, Ye X, Niu J, Wang W, Pfeffer L M, Shao Z-M, Wu Z-H*, Wu J*. MiRNA-621 sensitizes breast cancer to chemotherapy by suppressing FBXO11 and enhancing p53 activity. Oncogene, 2016; 35(4):448-458.
            8. Lou Feifei#, Sun Zhirong, Huang Naisi, Hu Zhen, Cao Ayong, Shen Zhenzhou, Shao Zhimin, Yu Peirong, Miao Changhong, Wu Jiong*. Epidural Combined with General Anesthesia versus General Anesthesia Alone in Patients Undergoing Free Flap Breast Reconstruction. Plastic and Reconstructive Surgery, 2016; 137(3):502e-509e.
            9. Niu, J#, Xue A, Chi Y, Xue J, Wang W, Zhao Z, Fan M, Yang CH, Shao Z-M, Pfeffer L M, Wu J*, Wu Z-H*. Induction of miRNA-181a by genotoxic treatments promotes chemotherapeutic resistance and metastasis in breast cancer. Oncogene, 2016 Mar 10; 35(10):1302-13.
            10. Chen Jia-ying#, Chen Jia-jian, Xue Jing-yan, Chen Ying, Liu Guang-yu, Han Qi-xia, Yang Wen-tao, Shen Zhen-zhou, Shao Zhi-min, Wu Jiong*. Predicting Non-sentinel Lymph Node Metastasis in a Chinese Breast Cancer Population with 1-2 Positive Sentinel Nodes: Development and Assessment of a New Predictive Nomogram. World J Surg, 2015; 39(12):2919-2927.
            11. Huang Naisi#,Chen Jiajian, Xue Jingyan, Yu Baohua, Chen Yanqiong, Yang Wentao, Shao Zhimin, Wu Jiong*. Breast Sclerosing Adenosis and Accompanying Malignancies: A Clinicopathological and Imaging Study in a Chinese Population. Medicine (Baltimore), 2015; 94(49):e2298-e2298.
            12. Huang Nai-Si#, Wu Jiong*. Nipple-sparing Mastectomy in Breast Cancer: From an Oncologic Safety Perspective. Chin Med J (Engl), 2015; 128(16):2256-2261.
            13. Jia-jian Chen#, Nai-si Huang#, Jing-yan Xue, Ben-long Yang, Guang-yu Liu, Gen-hong Di, Zhi-min Shao, Jiong Wu*. Current Status of Breast Reconstruction in Southern China: A 15 Year, Single Institutional Experience of 20,551 Breast Cancer Patients. Medicine (Baltimore), 2015; 94(34):e1399-e1399.
            14. Huang Xiaoyan#, Dugo Matteo, Callari Maurizio, Sandri Marco, De Cecco Loris, Valeri Barbara, Carcangiu Maria Luisa, Xue Jingyan, Bi Rui, Veneroni Silvia, Daidone Maria Grazia, Menard Sylvie, Tagliabue Elda, Shao Zhimin, Wu Jiong*, Orlandi, Rosaria*. Molecular portrait of breast cancer in China reveals comprehensive transcriptomic likeness to Caucasian breast cancer and low prevalence of luminal A subtype. Cancer Med, 2015; 4(7):1016-1030.
            15. Jiang Hong-Lin#, Sun He-Fen, Gao Shui-Ping, Li Liang-Dong, Hu Xin, Wu Jiong*, Jin Wei*. Loss of RAB1B promotes triple-negative breast cancer metastasis by activating TGF-beta/SMAD signaling. Oncotarget, 2015; 6(18):16352-16365.
            16. Naisi Huang#, Mengying Liu, Peirong Yu, Jiong Wu*. Antibiotic prophylaxis in prosthesis-based mammoplasty: A systematic review. International Journal of Surgery, 2015; 15:31-37.
            17. Chen Ying#, Shen Zhenzhou, Shao Zhimin, Yu Peirong, Wu Jiong*. Free Flap Monitoring Using Near-Infrared Spectroscopy: A Systemic Review. Annals of Plastic Surgery, 2015; 1(1).
            18. Chen Jia-jian#, Huang Nai-si, Xue Jing-yan, Quan Chen-lian,Tan Yu-long, Liu Guang-yu, Shao Zhi-min, Wu Jiong*. Surgical management for early-stage bilateral breast cancer patients in China. PLos One, 2015; 10(4):e0122692-e0122692.
            19. Chi Yayun#, Huang Sheng, Peng Haojie,Liu Mengying, Zhao Jun, Shao Zhiming, Wu Jiong*. Critical role of CDK11(p58) in human breast cancer growth and angiogenesis. BMC Cancer, 2015; 15:701-701.
            20. Niu Jixiao#, Shi Yuling, Xue Jingyan, Miao Ruidong, Huang Shengping, Wang Tianyi, Wu Jiong, Fu Mingui, Wu Zhao-Hui. USP10 inhibits genotoxic NF-kappaB activation by MCPIP1-facilitated deubiquitination of NEMO. The EMBO Journal, 2013; 32(24):3206-3219.
             
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