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            副研究員

            姚玲 副研究員
            副研究員,博士
            E-mail: yaoling@fudan.edu.cn
             

                  2011年畢業于上海交通大學醫學院,獲生物化學與分子生物學博士學位。畢業后任職于復旦大學附屬腫瘤醫院腫瘤研究所,乳腺癌研究所。期間于2016-2017年前往美國斯坦福大學醫學院訪問交流。主持和參加多項國家自然科學基金青年項目和面上項目,參加國家科技支撐計劃、上海市科委基礎研究項目等。研究成果發表于Nat Communication、The EMBO journal等國際核心雜志。


            研究領域:

              1.乳腺癌相關通路分子異常剪接與乳腺癌轉移的關系;
              2.乳腺癌相關通路分子異常表達及突變與乳腺癌發生發展的關系。


            代表性論著:

            1. Yao L#, Liu Y#, Cao Z, Li J, Huang Y, Hu X, Shao Z*. MicroRNA 493 is a prognostic factor in triple-negative breast cancer. Cancer Sci., 2018 Jul; 109(7):2294-2301.

              Src and transformation by an RPTPalpha splice mutant found in human tumours. The EMBO journal., 2011; 30(15):3200-3211.

            2. Chen L#, Yang L#, Yao L#, Kuang XY, Zuo WJ, Li S, Qiao F, Liu YR, Cao ZG, Zhou SL, Zhou XY, Yang WT, Shi JX, Huang W, Hu X, Shao ZM*. Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients. Nat Commun., 2018 Apr 10; 9(1):1357. 

            3. Yao L#, Chi Y#, Hu X#, Li S, Qiao F, Wu J, Shao ZM*. Elevated expression of RNA methyltransferase BCDIN3D predicts poor prognosis in breast cancer. Oncotarget, 2016 Aug 16; 7(33):53895-53902.

            4. Cao ZG#, Huang YN#, Yao L#, Liu YR, Hu X, Hou YF, Shao ZM*. Positive expression of miR-361-5p indicates better prognosis for breast cancer patients. J Thorac Dis., 2016 Jul; 8(7):1772-9.

            5. Chi Y#, Yao L#, Hu X, Huang S, Huang N, Li S, Shao Z*, Wu J*. The BMP inhibitor DAND5 in serum predicts poor survival in breast cancer. Oncotarget, 2016 Mar 22; 7(12):14951-62.

            6. Chen L, Yang L, Qiao F, Hu X, Li S, Yao L*, Yang XL, Shao ZM*. High Levels of Nucleolar Spindle-Associated Protein and Reduced Levels of BRCA1 Expression Predict Poor Prognosis in Triple-Negative Breast Cancer. PloS One, 2015 Oct 20; 10(10):e0140572.

            7. Wang L#, Yao L#, Zheng YZ, Xu Q, Liu XP, Hu X, Wang P, Shao ZM*. Expression of autophagy-related proteins ATG5 and FIP200 predicts favorable disease-free survival in patients with breast cancer. Biochem Biophys Res Commun., 2015 Mar 20; 458(4):816-22.

            8. Li K#, Yao L#, Chen L, Cao ZG, Yu SJ, Kuang XY, Hu X, Shao ZM*. ID2 predicts poor prognosis in breast cancer, especially in triple-negative breast cancer, and inhibits E-cadherin expression. Onco Targets Ther., 2014 Jun 18; 7:1083-94.

            9. Peng WT#, Hu X#, Yao L#, Jiang YZ, Shao ZM*. Elevated expression of Girdin in the nucleus indicates worse prognosis for patients with estrogen receptor-positive breast cancer. Ann Surg Oncol., 2014 Dec; 21.

            10. 1Yao L#, Li K#, Peng W, Lin Q, Li S, Hu X, Zheng X, Shao Z*. An aberrant spliced transcript of focal adhesion kinase is exclusively expressed in human breast cancer. J Transl Med., 2014 May 21; 12:136.

            11. Huang J#, Yao L#, Xu R, Wu H, Wang M, White BS, Shalloway D, Zheng X: Activation of

             
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