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2014年獲復旦大學生物化學與分子生物學博士學位,同年進入上海交通大學醫學院工作;2017年起任職于復旦大學生物醫學研究院和附屬腫瘤醫院。2019于哈佛大學David Scadden實驗室完成博士后研究。目前主要研究方向有1) 代謝物感知;2) 細胞代謝與腫瘤生物學。曾入選第四屆中國科協青年托舉工程項目,以項目負責人獲得基金委青年科學基金、面上項目、上海市晨光計劃、上海市優秀青年教師培養資助計劃等資助,以項目骨干參與基金委重大項目“代謝物及其感受調控異常在惡性腫瘤發生發展中的作用與機制”。研究成果發表于Molecular Cell、EMBO Journal、EMBO Reports、Cell Reports等雜志。
研究領域:
1.代謝物感知
細胞對代謝物的感知機制及其在腫瘤發生發展中的作用
2. 細胞代謝與腫瘤生物學
腫瘤發生發展關鍵事件的細胞代謝調控機制
代表性論著(#第一作者,*通訊作者):
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Yan Wei-Wei, Liang Yun-Liu,
Zhang Qi-Xiang, Wang Di, Lei Ming-Zhu, Qu Jia, He Xiang-Huo,Lei Qun-Ying, Wang Yi-Ping*. Arginine Methylation of SIRT7 Couples Glucose
Sensing with Mitochondria Biogenesis. EMBO Reports, 2018, 19(12): e46377
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Zhong Xing-Yu, Yuan
Xiu-Ming, Xu Ying-Ying, Yin Miao, Yan Wei-Wei, Zou Shao-Wu, Wei Li-Ming, Lu
Hao-Jie, Wang Yi-Ping*, Lei QY*.
CARM1 Methylates GAPDH to Regulate Glucose Metabolism and Is Suppressed in
Liver Cancer. Cell Reports, 2018, 24(12): 3207-3223
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Yi-Ping Wang*, Wei Zhou, Jian Wang, Xian Huang, Yong Zuo, Tian-Shi
Wang, Xue Gao, Ying-Ying Xu,Shao-Wu Zou,
Ying-Bing Liu, Jin-Ke Cheng*, Qun-Ying Lei*. Arginine Methylation of MDH1 by
CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer. Molecular
Cell, 2016, 64(4):673-687
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Wang Yiping, Xiao Mengtao, Chen Xiufei, Chen Leilei, Xu Yanping, Lv
Lei, Wang Pu, Yang Hui, Ma Shenghong, Lin Huaipeng, Jiao Bo, Ren Ruibao, Ye
Dan*, Guan Kunliang*, Xiong Yue*. WT1 Recruits TET2 to Regulate Its Target Gene
Expression and Suppress Leukemia Cell Proliferation. Molecular Cell,
2015, 57(4):662-673
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Wang Yiping, Zhou Lisha,
Zhao Yuzheng, Wang Shiwen, Chen Leilei, Liu Lixia,Ling Zhiqiang, Hu Fujun, Sun Yiping, Zhang Jinye, Yang Chen, Yang
Yi, Xiong Yue,Guan Kunliang, Ye Dan*.
Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis
and cell survival during oxidative stress. EMBO Journal, 2014,
33(12):1304-1320
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