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            副研究員

            秦毅 副研究員
            博士,副研究員
            E-mail: qinyi@fudanpci.org
             

              2003年本科畢業于吉林大學/沈陽藥科大學,2011年畢業于中國科學院生物化學與細胞生物學研究所,博士學位。曾于2011年-2012年在復旦大學分子病毒實驗室工作。自2012年起,一直在復旦大學腫瘤研究所/胰腺腫瘤研究所工作,2018年晉升為副研究員。主要從事胰腺癌的臨床和基礎研究,科研重點為胰腺癌的轉化研究和胰腺癌轉移機制研究等,已發表有關胰腺癌研究的SCI論著近20余篇。先后主持及參與上海科委自然科學基金,國家自然科學基金,國家杰青基金及其他省部級項目10余項。


            研究領域:

              胰腺癌的轉化研究和胰腺癌轉移機制研究,主要研究方向如下:
              1. 驅動基因KRAS突變促進胰腺癌侵襲轉移的分子機制; 
              2. 抑癌基因FBW7在胰腺癌中的功能;
              3. 腫瘤代謝異常調控胰腺癌惡性潛能的分子機制。


            代表性論著:

            1. Liang C#, Shi S#, Qin Y#, Meng Q, Hua J, Hu Q, Ji S, Zhang B, Xu J, Yu XJ. Localisation of PGK1 determines metabolic phenotype to balance metastasis and proliferation in patients with SMAD4-negative pancreatic cancer. Gut, 2019 Oct 14.
            2. Qin Y#, Hu Q#, Ji S, Xu J, Dai W, Liu W, Xu W, Sun Q, Zhang Z, Ni Q, Yu X, Zhang B, Xu X. Homeodomain-interacting protein kinase 2 suppresses proliferation and aerobic glycolysis via ERK/cMyc axis in pancreatic cancer. Cell Prolif, 2019 May.
            3. Qin Y#, Hu Q#, Xu J#, Ji S, Dai W, Liu W, Xu W, Sun Q, Zhang Z, Ni Q, Zhang B, Yu X, Xu X PRMT5 enhances tumorigenicity and glycolysis in pancreatic cancer via the FBW7/cMyc axis.  Cell Commun Signal, 2019 Mar.
            4. Hu Q#, Qin Y#, Ji S#, Xu W, Liu W, Sun Q, Zhang Z, Liu M, Ni Q, Yu X, Xu X. UHRF1 promotes aerobic glycolysis and proliferation via suppression of SIRT4 in pancreatic cancer. Cancer Lett, 2019 Jun.
            5. Qiangsheng Hu#Yi Qin#, Jinfeng Xiang#, Wensheng Liu, Wenyan Xu, Qiqing Sun, Shunrong Ji, Jiang Liu, Zheng Zhang, Quanxing Ni, Jin Xu, Xianjun Yu*, Bo Zhang*. dCK negatively regulates the NRF2/ARE axis and ROS production in pancreatic cancer. Cell Proliferation, 2018; Apr 27: e12456. doi: 10.1111/cpr.12456. [Epub ahead of print]
            6. Chen Liang#, Yi Qin#, Bo Zhang#, Shunrong Ji, Si Shi, Wenyan Xu,?Jiang Liu, Jinfeng Xiang, Dingkong Liang, Qiangsheng Hu, Quanxing Ni, Jin Xu, and Xianjun Yu*. Oncogenic KRAS Targets MUC16/CA125 in Pancreatic Ductal Adenocarcinoma. Molecular Cancer Research, 2017; 15(2):201-212.
            7. Qiangsheng Hu#, Yi Qin#, Bo Zhang#, Chen Liang, Shunrong Ji, Si Shi, Wenyan Xu, Jinfeng Xiang, Dingkong Liang, Quanxing Ni, Xianjun Yu*, Jin Xu*. FBW7 increases the chemosensitivity of pancreatic cancer cells to gemcitabine through upregulation of ENT1. Oncology Reports, 2017; 38(4):2069-2077.
            8. Shunrong Ji#, Yi Qin#, Chen Liang#, Run Huang, Si Shi, Jiang Liu, Kaizhou Jin, Dingkong Liang, Wenyan Xu, Bo Zhang, Liang Liu, Chen Liu, Jin Xu, Quanxing Ni, Paul J. Chiao, Min Li, and Xianjun Yu*. FBW7 (F-box and WD Repeat Domain-Containing 7) Negatively Regulates Glucose Metabolism by Targeting the c-Myc/TXNIP (Thioredoxin-Binding Protein) Axis in Pancreatic Cancer. Clinical Cancer Research, 2016; 22(15):3950-60.
            9. Chen Liang#, Yi Qin#, Bo Zhang#, Shunrong Ji, Si Shi, Wenyan Xu, Jiang Liu, Jinfeng Xiang, Dingkong Liang, Qiangsheng Hu, Quanxing Ni, Xianjun Yu*, Jin Xu*. ARF6, induced by mutant Kras, promotes proliferation and Warburg effect in pancreatic cancer. Cancer Letters, 2016; 388:303-311.
            10. Chen Liang#, Yi Qin#, Bo Zhang, Shunrong Ji, Si Shi, Wenyan Xu, Jiang Liu, Jinfeng Xiang, Dingkong Liang, Qiangsheng Hu, Liang Liu, Chen Liu, Guopei Luo, Quanxing Ni, Jin Xu*, and Xianjun Yu*. Energy sources identify metabolic phenotypes in pancreatic cancer. Acta Biochim Biophys Sin, 2016; 48(11):969-979.
            11. Chen Liang#, Yi Qin#, Bo Zhang, Shunrong Ji, Si Shi, Wenyan Xu, Jiang Liu, Jinfeng Xiang, Dingkong Liang, Qiangsheng Hu, Quanxing Ni, Jin Xu, Xianjun Yu*. Metabolic plasticity in heterogeneous pancreatic ductal adenocarcinoma. Biochimica et Biophysica Acta, 2016; 1866(2):177-188.
            12. B. Zhang#, J. Xu#, C. Li#, S. Shi, S. Ji, W. Xu, J. Liu, K. Jin, D. Liang, C. Liang, L. Liu, C. Liu, Y. Qin* and X. Yu*. MBD1 is an Epigenetic Regulator of KEAP1 in Pancreatic Cancer. Current Molecular Medicine, 2016; 16(4):404-11.
            13. S. Shi#, J. Xu#, B. Zhang, S. Ji, W. Xu, J. Liu, K. Jin, D. Liang, C. Liang, L. Liu, C. Liu, Y. Qin* and X. Yu*. VEGF Promotes Glycolysis in Pancreatic Cancer via HIF1α Up-Regulatio. Current Molecular Medicine,2016; 16(4):394-403.
            14. Qingguo Li#, Yi Qin# Ping Wei, Peng Lian, Yaqi Li, Ye Xu, Xinxiang Li, Dawei Li, and Sanjun Cai*. Gas1 Inhibits Metastatic and Metabolic Phenotypes in Colorectal Carcinoma, Molecular Cancer Research, 2016; 14(9):830-40.
            15. Qing-Hai Ye# ,Wen-Wei Zhu#, Ju-Bo Zhang#, Yi Qin#, Ming Lu, Guo-Ling Lin, Lei Guo, Bo Zhang, Zhen-Hai Lin, Stephanie Roessler, Marshonna Forgues,Hu-Liang Jia, Lu Lu, Xiao-Fei Zhang, Bao-Feng Lian, Lu Xie,Qiong-Zhu Dong, Zhao-You Tang,Xin Wei Wang*,and Lun-Xiu Qin*. GOLM1 Modulates EGFR/RTK Cell-Surface Recycling to Drive Hepatocellular Carcinoma Metastasis. Cancer Cell, 2016; 30(3):444-58.
            16. Shunrong Ji#, Yi Qin#, Si Shi, Xiangyuan Liu, Hongli Hu, Hu Zhou, Jing Gao, Bo Zhang, Wenyan Xu, Jiang Liu, Dingkong Liang, Liang Liu, Chen Liu, Jiang Long, Haijun Zhou, Paul J Chiao, Jin Xu, Quanxing Ni, Daming Gao, Xianjun Yu*. ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer. Cell Research, 2015; 25(5):561-73.
            17. Si Shi#, Shunrong Ji#, Yi Qin#, Jin Xu, Bo Zhang, Wenyan Xu, Jiang Liu, Jiang Long, Chen Liu, Liang Liu, Quanxing Ni, Xianjun Yu*. Metabolic tumor burden is associated with major oncogenomic alterations and serum tumor markers in patients with resected pancreatic cancer. Cancer Letters, 2015; 360(2):227-33.
            18. Wantong Yao#, Shunrong Ji#, Yi Qin#, Jingxuan Yang, Jin Xu, Bo Zhang, Wenyan Xu, Jiang Liu, Si Shi, Liang Liu, Chen Liu, Jiang Long, Quanxing Ni, Min Li and Xianjun Yu*. Profilin-1 suppresses tumorigenicity in pancreatic cancer through regulation of the SIRT3-HIF1α axis. Molecular Cancer, 2014; 13:187.
            19. Yi Qin#, Wenwei Zhu# , Wenyan Xu#, Bo Zhang, Si Shi, Shunrong Ji, Jiang Liu, Jiang Long, Chen Liu, Liang Liu , Jin Xu*, Xianjun Yu*. LSD1 sustains pancreatic cancer growth via maintaining HIF1a-dependent glycolytic process. Cancer Letters, 2014; 347(2):225-32.
            20. Yanfeng Liu#, Ju-Bo Zhang#, Yi Qin#, Wei Wang, Lili Wei, Yigang Teng, Lei Guo, Bo Zhang, Zhenhai Lin, Jing Liu, Zheng-Gang Ren, Qing-Hai Ye, and Youhua Xie*. PROX1 promotes hepatocellular carcinoma metastasis by way of up-regulating Hypoxia-Inducible Factor 1a expression and protein stability. Hepatology, 2013; 58(2):692-705.
             
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