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1995年與1998年于華東師范大學獲本科及理學碩士學位;2003年于復旦大學獲理學博士學位。2003年至2006年于美國UT M.D.安德森癌癥中心從事博士后研究。2006年至2013年任職于上海市腫瘤研究所癌基因及相關基因國家重點實驗室,研究員,PI。2014年至今任職于復旦大學生物醫學研究院及復旦大學附屬腫瘤醫院/腫瘤研究所,研究員,博士生導師,復旦大學特聘教授。
2011年國家杰出青年科學基金獲得者、2017年入選第三批國家“萬人計劃”領軍人才。曾入選科技部中青年創新領軍人才、教育部新世紀優秀人才、上海市優秀學術帶頭人、上海市醫學領軍人才、上海市浦江人才、上海市教委曙光學者、上海衛生系統優秀學科帶頭人;曾獲吳孟超醫學基金獎一等獎、銀蛇獎、明治生命科學獎;曾獲教育部自然科學獎二等獎及上海醫學科技獎二等獎。
研究領域為腫瘤分子生物學,主要從事消化系惡性腫瘤發生與轉移的分子機理研究,已發表論文100余篇,包括Nature
Cell Biology, Gastroenterology, Hepatology, Cell Research, Nature
Communications, Nucleic Acids Research, Cancer Research, Clinical Cancer
Research, Cell Reports, Oncogene, Science Signaling 等國際學術期刊;論文被引6650余次, H-index為42(至2019-12)。
研究領域:
腫瘤分子生物學,研究方向包括:
1.非編碼RNA功能及分子機制;
2.RNA可變剪接異常及調控機制;
3.轉錄重編程及表觀調控機制。
研究團隊:
代表性論著(*為通訊作者):
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Hu Z, Dong L, Li S, Li Z, Qiao Y, li Y, Ding J, Chen
z, Wu Y, Wang Z, Huang S, Gao Q*, Zhao Y*, He X*. Splicing Regulator p54nrb/NONO
Enhances Carcinogenesis Through Oncogenic Isoform Switch of BIN1 in
Hepatocellular Carcinoma. Hepatology, 2019 Dec 9. doi:10.1002/hep.31062.
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Zheng Q, Zhao J, Yu H, Zong H, He X, Zhao Y, Li Y, Wang
Y, Bao Y, Li Y, Chen B, Guo W, Wang Y, Chen Z, Zhao Y, Wang L*, He X*, Huang S*. Tumor-Specific Transcripts Are Frequently Expressed in
Hepatocellular Carcinoma With Clinical Implication and Potential Function. Hepatology, 2019 Jun 7. doi: 10.1002/hep.30805.
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Li Y, Zhao J, Yu S, Wang Z, He X, Su Y, Guo T, Sheng H,
Chen J, Zheng Q, Li Y, Guo W, Cai X, Shi G, Wu J, Wang L, Wang P, He X*, Huang S*. Extracellular Vesicles Long RNA Sequencing Reveals Abundant
mRNA, circRNA, and lncRNA in Human Blood as Potential Biomarkers for Cancer
Diagnosis. Clin Chem, 2019 Jun; 65(6): 798-808.
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Li S,
Hu Z, Zhao Y, Huang S, He X*. Transcriptome-Wide Analysis Reveals the
Landscape of Aberrant Alternative Splicing Events in Liver Cancer. Hepatology, 2019 Jan; 69(1): 359-375.
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Li S, Zhang J, Huang S*, He X*. Genome-wide analysis
reveals that exon methylation facilitates its selective usage in the human
transcriptome. Brief Bioinform, 2018 Sep 28; 19(5): 754-764.
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Li Z,
Zhang J, Liu X, Li S, Wang Q, Chen D, Hu Z, Yu T, Ding J, Li J, Yao M, Fan J, Huang
S, Gao Q*, Zhao Y*, He X*. The LINC01138 drives
malignancies via activating arginine methyltransferase 5 in hepatocellular
carcinoma. Nat Commun, 2018 Apr 20; 9(1): 1572.
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Wang H, Liang L, Dong Q, Huan L, He J, Li B, Yang C, Jin
H, Wei L, Yu C, Zhao F, Li J, Yao M, Qin W*, Qin L*, He X*. Long noncoding RNA miR503HG, a prognostic indicator,
inhibits tumor metastasis by regulating the HNRNPA2B1/NF-κB pathway in
hepatocellular carcinoma. Theranostics, 2018 April 15; 8(10): 2814-2829.
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Guo W, Hu Z, Bao Y, Li Y, Li S, Zheng Q, Lyu D, Chen D,
Yu T, Li Y, Zhu X, Ding J, Zhao Y, He X*, Huang S*. A LIN28B
Tumor-Specific Transcript in Cancer. Cell Rep, 2018 Feb
20; 22(8): 2016-2025.
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Zhang J, Li Z, Liu L, Wang Q, Li S, Chen D, Hu Z, Yu
T, Ding J, Li J, Yao M, Huang S, Zhao Y*, He X*. Long noncoding RNA TSLNC8
is a tumor suppressor that inactivates the interleukin-6/STAT3 signaling
pathway. Hepatology, 2018 Jan; 67(1): 171-187.
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Chen Z, Lu X, Jia D, Jing Y, Chen D, Wang Q, Zhao F, Yao
M, Cong W, He X*. Hepatic SMARCA4 predicts HCC recurrence and promotes tumour
cell proliferation by regulating SMAD6 expression. Cell Death Dis, 2018 Jan 19; 9(2): 59.
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Yu T, Zhao Y, Hu Z, Li J, Chu D, Zhang J, Li Z, Chen
B, Zhang X, Pan H, Li S, Lin H, Liu L, Yan M, He X*, Yao M*. MetaLnc9 Facilitates Lung
Cancer Metastasis via a PGK1-Activated AKT/mTOR Pathway. Cancer Res, 2017 Nov 1; 77(21): 5782-5794.
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Zheng Q, Bao C, Guo W, Li S, Chen J, Chen B, Luo Y,
Lyu D, Li Y, Shi G, Liang L, Gu J, He X*, Huang S*. Circular RNA profiling reveals an abundant circHIPK3
that regulates cell growth by sponging multiple miRNAs. Nat Commun, 2016
Apr 6; 7: 11215.
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Qiu Z, Guo W, Wang Q, Chen Z, Huang S, Zhao F, Yao M,
Zhao Y*, He X*. MicroRNA-124 reduces the pentose phosphate pathway
and proliferation by targeting PRPS1 and RPIA mRNAs in human colorectal cancer
cells. Gastroenterology, 2015 Nov; 49(6): 1587-1598.e11.
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Guo W, Qiu Z, Wang Z, Wang Q, Tan N, Chen T, Chen Z,
Huang S, Gu J, Li J, Yao M, Zhao Y*, He X*. MiR-199a-5p is negatively
associated with malignancies and regulates glycolysis and lactate production by
targeting hexokinase 2 in liver cancer. Hepatology, 2015 Oct; 62(4): 1132-44.
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Li Y, Zheng Q, Bao C, Li S, Guo W, Zhao J, Chen D, Gu
J, He X*, Huang S*. Circular RNA is enriched and stable in exosomes: a
promising biomarker for cancer diagnosis. Cell Res, 2015 Aug; 25(8): 981-4.
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Bao C, Li Y, Huan L, Zhang Y, Zhao F, Wang Q, Liang L,
Ding J, Liu L, Chen T, Li J, Yao M, Huang S*, He X*. NF-κB signaling relieves
negative regulation by miR-194 in hepatocellular carcinoma by suppressing the
transcription factor HNF-1α. Sci Signal, 2015 Jul 28; 8(387): ra75.
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Chen Z, Wang Z, Guo W, Zhang Z, Zhao F, Zhao Y, Jia D,
Ding J, Wang H, Yao M, He X*. TRIM35 Interacts with pyruvate kinase isoform M2 to
suppress the Warburg effect and tumorigenicity in hepatocellular carcinoma. Oncogene, 2015 Jul 23; 34(30): 3946-56.
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Jia D, Dong R, Jing Y, Xu D, Wang Q, Chen L, Li Q,
Huang Y, Zhang Y, Zhang Z, Liu L, Zheng S, Xia Q, Wang H*, Dong K*, He X*. Exome sequencing of
hepatoblastoma reveals novel mutations and cancer genes in the Wnt pathway and
ubiquitin ligase complex. Hepatology, 2014 Nov; 60(5): 1686-96.
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Gao Q, Zhao YJ, Wang XY, Guo WJ, Gao S, Wei L, Shi JY,
Shi GM, Wang ZC, Zhang YN, Shi YH, Ding J, Ding ZB, Ke AW, Dai Z, Wu FZ, Wang
H, Qiu ZP, Chen ZA, Zhang ZF, Qiu SJ, Zhou J*, He XH*, Fan J*. Activating mutations in PTPN3 promote
cholangiocarcinoma cell proliferation and migration and are associated with tumor
recurrence in patients. Gastroenterology, 2014 May; 146(5):
1397-407.
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Wang Q, Huang Z, Guo W, Ni S, Xiao X, Wang L, Huang D,
Tan C, Xu Q, Zha R, Zhang J, Sheng W, He
X*, Du X*. microRNA-202-3p inhibits
cell proliferation by targeting ADP-ribosylation factor-like 5A in human
colorectal carcinoma. Clin Cancer Res, 2014 Mar 1; 20(5): 1146-57.
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Jia D, Jing Y, Zhang Z, Liu L, Ding J, Zhao F, Ge C,
Wang Q, Chen T, Yao M, Li J, Gu J, He X*. Amplification of MPZL1/PZR promotes tumor cell
migration through Src-mediated phosphorylation of cortactin in hepatocellular
carcinoma. Cell Res, 2014
Feb; 24(2): 204-17.
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Ding J, Huang S, Wang Y, Tian Q, Zha R, Shi H, Wang Q,
Ge C, Chen T, Zhao Y, Liang L, Li J, He
X*. Genome-wide screening
reveals that miR-195 targets the TNF-α/NF-κB pathway by down-regulating IκB
kinase alpha and TAB3 in hepatocellular carcinoma. Hepatology, 2013 Aug; 58(2): 654-66.
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Ke G, Liang L, Yang JM, Huang X, Han D, Huang S, Zhao
Y, Zha R, He X*, Wu X*. MiR-181a confers resistance of cervical cancer to radiation
therapy through targeting the pro-apoptotic PRKCD gene. Oncogene, 2013 Jun
20; 32(25): 3019-27.
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Zheng B, Liang L, Huang S, Zha R, Liu L, Jia D, Tian
Q, Wang Q, Wang C, Long Z, Zhou Y, Cao X, Du C, Shi Y*, He X*. MicroRNA-409 suppresses
tumour cell invasion and metastasis by directly targeting radixin in gastric
cancers. Oncogene, 2012 Oct 18; 31(42): 4509-16.
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Gao Q, Zhao YJ, Wang XY, Qiu SJ, Shi YH, Sun J, Yi Y,
Shi JY, Shi GM, Ding ZB, Xiao YS, Zhao ZH, Zhou J*, He XH*, Fan J*. CXCR6 upregulation contributes
to a proinflammatory tumor microenvironment that drives metastasis and poor
patient outcomes in hepatocellular carcinoma. Cancer Res, 2012 Jul 15; 72(14): 3546-56.
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Ying Q, Liang L, Guo W, Zha R, Tian Q, Huang S, Yao J,
Ding J, Bao M, Ge C, Yao M, Li J, He X*. Hypoxia-inducible microRNA-210 augments the
metastatic potential of tumor cells by targeting vacuole membrane protein 1 in
hepatocellular carcinoma. Hepatology, 2011 Dec; 54(6): 2064-75.
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Zheng B, Liang L, Wang C, Huang S, Cao X, Zha R, Liu L,
Jia D, Tian Q, Wu J, Ye Y, Wang Q, Long Z, Zhou Y, Du C, He X*, Shi Y*. MicroRNA-148a suppresses
tumor cell invasion and metastasis by downregulating ROCK1 in gastric cancer. Clin
Cancer Res, 2011 Dec 15; 17(24): 7574-83.
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Jia D, Wei L, Guo W, Zha R, Bao M, Chen Z, Zhao Y, Ge
C, Zhao F, Chen T, Yao M, Li J, Wang H, Gu J, He X*. Genome-wide copy number
analyses identified novel cancer genes in hepatocellular carcinoma. Hepatology,
2011 Oct; 54(4): 1227-36.
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Huang Z, Huang S, Wang Q, Liang L, Ni S, Wang L, Sheng
W, He X*, Du X*. MicroRNA-95 promotes cell
proliferation and targets sorting Nexin 1 in human colorectal carcinoma. Cancer
Res, 2011 Apr 1; 71(7): 2582-9.
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Zhao Y, Wang X, Wang T, Hu X, Hui X, Yan M, Gao Q,
Chen T, Li J, Yao M, Wan D, Gu J*, Fan J*, He X*. Acetylcholinesterase, a key prognostic predictor for
hepatocellular carcinoma, suppresses cell growth and induces
chemosensitization. Hepatology, 2011
Feb; 53(2): 493-503.
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Liang L, Wong CM, Ying Q, Fan DN, Huang S, Ding J, Yao
J, Yan M, Li J, Yao M, Ng IO, He X*. MicroRNA-125b suppressesed human liver cancer cell
proliferation and metastasis by directly targeting oncogene LIN28B2. Hepatology, 2010 Nov; 52(5): 1731-40.
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Huang S, Wu S, Ding J, Lin J, Wei L, Gu J, He X*. MicroRNA-181a modulates gene expression of zinc
finger family members by directly targeting their coding regions. Nucleic
Acids Res, 2010 Nov; 38(20):7211-8.
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Ding J, Huang S, Wu S, Zhao Y, Liang L, Yan M, Ge C,
Yao J, Chen T, Wan D, Wang H, Gu J, Yao M, Li J, Tu H, He X*. Gain of miR-151 on
chromosome 8q24.3 facilitates tumour cell migration and spreading through
downregulating RhoGDIA. Nat Cell Biol, 2010 Apr; 12(4): 390-9.
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Wu S, Huang S, Ding J, Zhao Y, Liang L, Liu T, Zhan R*, He X*. Multiple microRNAs
modulate p21Cip1/Waf1 expression by directly targeting its 3' untranslated
region. Oncogene, 2010
Apr 15; 29(15):2302-8.
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Yao J, Liang L, Huang S, Ding J, Tan N, Zhao Y, Yan M,
Ge C, Zhang Z, Chen T, Wan D, Yao M, Li J, Gu J, He X*. MicroRNA-30d promotes
tumor invasion and metastasis by targeting Galphai2 in hepatocellular
carcinoma. Hepatology, 2010 Mar; 51(3): 846-56.
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