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            專職PI
            黃勝林 研究員
            研究員,博士生導師
            E-mail: slhuang@fudan.edu.cn
             

              2003年于福建醫科大學獲臨床醫學學士學位,2006年與2009年于上海交通大學醫學院獲生物化學與分子生物學碩士學位及腫瘤學博士學位。2009年博士畢業后留在上海市腫瘤研究所癌基因及相關基因國家重點實驗室工作,2011年至2013年在斯坦福大學醫學院做博士后,2013年9月起任復旦大學附屬腫瘤醫院/腫瘤研究所和生物醫學研究院PI。主要從事腫瘤表觀遺傳和生物信息學研究,建立了相關的RNA測序、生物信息方法和數據庫(exLR-seq,ASJA,exoRBase),提出癌癥中存在豐富的腫瘤特異轉錄本,解析細胞外囊泡/外泌體內新的RNA組分和應用。迄今發表SCI論文40余篇,被引超過3000次,主要研究成果發表于Nature Cell Biology, Cell Research, Nature Communications, Gut, Hepatology, Nucleic Acids Research, Cell Reports等專業雜志上。主持國家自然基金項目4項,申請發明專利3項,作為主要完成人獲教育部自然科學獎二等獎及上海醫學科技獎二等獎。


            研究領域:

              腫瘤表觀遺傳及生物信息學研究,主要包括:
              1. 腫瘤相關RNA/特異轉錄本鑒定及在腫瘤中的作用機制和應用研究;
              2. 血液細胞外囊泡/外泌體RNA鑒定及生物信息分析在腫瘤中的應用研究。



            研究團隊:

              研究助理:   李焱 博士、鄭秋鵬 博士
              博士研究生:李玉琛、賴洪燕
              碩士研究生:趙晶晶、黎  琴


            代表性論著:

            1. Qiupeng Zheng#, Jingjing Zhao#, Hui Yu, Huajie Zong, Xigan He, Yiming Zhao, Yan Li, Yu Wang, Yichao Bao, Yuchen Li, Bing Chen, Weijie Guo, Yilin Wang, Zhiao Chen, Yingjun Zhao, Lu Wang*, Xianghuo He*, Shenglin Huang*. Tumor-specific Transcripts are Frequently Expressed in Hepatocellular Carcinoma with Clinical Implication and Potential Function. Hepatology. 2019. DOI: 10.1002/hep.30805
            2. Yu S#, Li Y#, Liao Z#, Wang Z#, Wang Z, Li Y, Qian L, Zhao J, Zong H, Kang B, Zou WB, Chen K, He X, Meng Z, Chen Z*, Huang S*, Wang P*. Plasma extracellular vesicle long RNA profiling identifies a diagnostic signature for the detection of pancreatic ductal adenocarcinoma. Gut. 2019. doi: 10.1136/gutjnl-2019-318860.
            3. Jingjing Zhao#, Qin Li#, Yuchen Li, Xianghuo He, Qiupeng Zheng*, Shenglin Huang*. ASJA: Assembling Splice Junctions Analysis. Computational and Structural Biotechnology Journal, 2019; 17:1143-1150.
            4. Yuchen Li#, Jingjing Zhao#, Shulin Yu, Zhen Wang, Xigan He, Yonghui Su, Tianan Guo, Haoyue Sheng, Jie Chen, Qiupeng Zheng, Yan Li, Weijie Guo, Xiaohong Cai, Guohai Shi, Jiong Wu, Lu Wang, Peng Wang*, Xianghuo He*, Shenglin Huang*. Extracellular vesicles long RNA sequencing reveals abundant mRNA, circRNA and lncRNA in human blood as biomarkers for cancer diagnosis. Clinical Chemistry,2019; 65(6):798-808.
            5. Guo W#, Hu Z#, Bao Y, Li Y, Li S, Zheng Q, Lyu D, Chen D, Yu T, Li Y, Zhu X, Ding J, Zhao Y, He X*, Huang S*. A LIN28B Tumor-Specific Transcript in Cancer. Cell Reports, 2018; 22(8):2016-2025.
            6. Shengli Li, Yuchen Li, Bing Chen, Jingjing Zhao, Shulin Yu, Yan Tang, Qiupeng Zheng, Yan Li, Peng Wang, Xianghuo He, Shenglin Huang*. exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes. Nucleic Acids Research, 2018; 6:D106–D112.
            7. Jie Chen#, Yan Li#, Qiupeng Zheng, Chunyang Bao, Jian He, Bing Chen, Dongbin Lyu, Biqiang Zheng, Yu Xu, Ziwen Long, Ye Zhou, Huiyan Zhu, Yanong Wang, Xianghuo He, Yingqiang Shi*, Shenglin Huang*. Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer. Cancer Letters, 2017; 388: 208-19.
            8. Qiupeng Zheng#, Chunyang Bao#, Weijie Guo, Shuyi Li, Jie Chen, Bin Chen, Yanting Luo, Dongbin Lyu, Yan Li, Guohai Shi, Linhui Liang, Jianren Gu, Xianghuo He*, Shenglin Huang*. Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs. Nature Communications, 2016; 7:11215. DOI: 10.1038/ncomms11215.
            9. Yan Li#, Qiupeng Zheng#, Chunyang Bao, Shuyi Li, Weijie Guo, Jiang Zhao, Di Chen, Jianren Gu, Xianghuo He*, Shenglin Huang*. Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Cell Research, 2015; 25(8):981-4.
            10. Chunyang Bao#, Yan Li#, Lin Huan, Yuannv Zhang, Fangyu Zhao, Qifeng Wang, Linhui Liang, Jie Ding, Li Liu, Taoyang Chen, Jinjun Li, Ming Yao, Shenglin Huang*, Xianghuo He*. NF-kB signaling relieves negative regulation by miR-194 in hepatocellular carcinoma by suppressing the transcription factor HNF-1a. Science Signaling, 2015; 8(387):ra75.
            11. Zheng Q, Cai X, Tan MH, Schaffert S, Arnold CP, Gong X, Chen CZ*, Huang S*. Precise gene deletion and replacement using the CRISPR/Cas9 system in human cells. Biotechniques, 2014; 57(3):115-24.
             
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