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            專職PI

            雷群英 教授
            教授,博士生導師
            E-mail: qlei@fudan.edu.cn
             

              1993年獲江西醫學院學士學位,1999年獲蘇州醫學院碩士學位,2002年獲上海醫科大學醫學博士學位,之后在美國加州大學洛杉磯分校做博士后研究,2006年被復旦大學引進,先后擔任復旦大學基礎醫學院生化系副教授、教授和系主任,生物醫學研究院(IBS)PI2017年調入復旦大學附屬腫瘤醫院并同時兼任IBS PIhttp://ibs.fudan.edu.cn/peoplemore.php?id=230&tid=1)。目前擔任中國細胞生物學會細胞代謝分會會長,中國生物化學與分子生物學會基礎醫學專業分會副理事長和上海市生物化學與分子生物學會副理事長。

              長江特聘教授,萬人計劃入選者,享受政府特殊津貼專家。研究方向為腫瘤代謝,成果以通訊作者/共同通訊作者在Cancer cellCell MetabolismMolecular CellNature Cell Biology, Nature CommunicationsJ.Clin. Invest. 等雜志發表。
              先后主持基金委國家杰出青年、重點項目和重大項目、科技部國家重大科學研究計劃項目;入選上海市衛生系統"優秀學科帶頭人"、上海市教委"曙光學者"、上海市優秀學術帶頭人、科技部中青年科技領軍人才。獲明治乳業生命科學杰出獎、教育部自然科學一等獎和二等獎、中國青年女科學家獎、中國女醫師協會五洲女子科技獎、上海市自然科學一等獎、上海市科技精英提名獎、上海市自然科學牡丹獎、普康獎教金、上海育才獎、上海市三八紅旗手標兵和全國三八紅旗手等榮譽。


            研究領域:

              聚焦腫瘤代謝領域的關鍵科學問題,主要圍繞以下三個方向開展研究:

                  1. 腫瘤細胞如何感受并利用營養物質

                  2. 腫瘤代謝重塑過程中關鍵代謝酶的調控機制

                  3. 腫瘤代謝與腫瘤微環境的相互作用機理


            研究團隊:




            代表性論著:(*為通訊作者)

            1. Li JT#, Yin M#, Wang D#, Wang J, Lei MZ, Zhang Y, Liu Y, Zhang L, Zou SW, Hu LP, Zhang ZG, Wang YP, Wen WY, Lu HJ, Chen ZJ, Su D, Lei QY*. BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma. Nature Cell Biology, 2020; 22:161-174. https://doi.org/10.1038/s41556-019-0455-6. (Highlight: Preview in Nature Cell Biology)
            2. Guo J#, Zhang Q, Su Y, Lu X, Wang Y, Yin M, Hu W, Wen W, Lei QY*. Arginine methylation of ribose-5-phosphate isomerase A senses glucose to promote human colorectal cancer cell survival. Sci China Life Sci, 2020 Mar 6. doi: 10.1007/s11427-019-1562-y. [Epub ahead of print]
            3. Liu Y#, Guo JZ#, Liu Y#, Wang K, Ding WC, Wang H, Liu X, Zhou ST, Lu XC, Yang HB, Xu CY, Gao W, Zhou L, Wang YP, Hu WG, Wei YQ, Huang CH*Lei QY*. Nuclear Lactate Dehydrogenase A Senses ROS to Produce a-Hydroxybutyrate for HPV-Induced Cervical Tumor Growth. Nature Commun, 2018; 9: 4429.  doi: 10.1038/s41467-018-06841-724.
            4. Zhong XY, Yuan XM, Xu YY, Yin M, Yan WW, Zou SW, Wei LM, Lu HJ, Wang YP*Lei QY*. CARM1 Methylates GAPDH to Regulate Glucose Metabolism and Is Suppressed in Liver Cancer. Cell Reports, 2018; 24(12): 3207-3223.doi: 10.1016/j.celrep.2018.08.066.
            5. Xia S, Lin R, Jin L, Zhao L, Kang HB, Pan Y, Liu S, Qian G, Qian Z, Konstantakou E, Zhang B, Dong JT, Chung YR, Abdel-Wahab O, Merghoub T, Zhou L, Kudchadkar RR, Lawson DH, Khoury HJ, Khuri FR, Boise LH, Lonial S, Lee BH, Pollack BP, Arbiser JL, Fan J*Lei QY*, Chen J*. Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth. Cell Metabolism, 2017 Feb 7; 25(2):358-373.  (Highlight: Nature)
            6. Zhang Y#, Xu YY#, Zhao XN, Li JT, Yang HB, Zhang M, Li, Yao CB, Yin M*, Chen J*, Lei QY*. Acetylation targets HSD17B4 for degradation via CMA pathway in response to E1. Autophagy2017 Mar 413(3):538-553.
            7. Wang YP*,Wang J,Gao X, Xu YY, Cheng JK*Lei QY*. Arginine Methylation of MDH1 by CARM1 Inhibits Non-canonical Glutamine Metabolism and Suppresses Pancreatic Cancer. Molecular Cell, 2016; 64:673–687. (Highlight: Cancer Discovery)
            8. Gao X#, Lin SH#,Ren F, Li1 JT, Chen JJ, Yao CB,Yang HB,Jiang SX, Yan GQ, Wang D, Wang Y, Liu Y, Cai Z, Xu YY, Chen J, Yu W, Yang PY*Lei QY*. Acetate Functions as an Epigenetic Metabolite to Promote Lipid Synthesis under Hypoxia. Nature Commun, 2016 Jun 30; 7:11960. doi: 10.1038/ncomms11960.
            9. Yang HB#., Xu YY#*., Zhao XN, Zou SW*., Zhang Y., Zhang M., Li JT, Ren F., Wang LY., Lei QY*. Acetylation of MAT IIα represses tumour cell growth and is decreased in human hepatocellularcancer. Nature Commun, 2015 Apr 30; 6:6973. doi: 10.1038/ncomms7973.
            10. Zha, ZY., Han, XR., Matthew D. Smith, Liu, Y., Patrick M. Giguère, DraganaKopanja, PradipRaychaudhuri, David P. Siderovski, Guan, KL*., Lei, QY*. , and Xiong, Y*. A non- canonical function of Gβ as a subunit of E3 ligase in targeting GRK2 ubiquitylation. Molecular Cell, 2015; 58(5):794-803.
            11. Zhou, X#., Wang, SY#., Wang, Z., Feng, X., Liu, P., Lv, X-B., Li, F-L., Yu, F-x., Sun,YP., Yuan, HX., Zhu, HG., Xiong,Y*., Lei, QY*., Guan, KL*. Estrogen Activates TAZ via GPER in Invasive Ductal Breast Carcinoma. J Clin Invest, 2015; 125(5):2123-35.
            12. Zhao, D., Mo, Y., Li, MT., Zou,SW., Cheng, ZL., Sun, Y-P., Xiong, Y*., Guan, KL*., Lei, QY*. NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells. J Clin Invest, 2014; 124(12):5453-65.
            13. Li T, Liu F, Feng X, Wang Z, Das I, Xu Y, Zhou X, Sun Y, Guan KL , Xiong Y, Lei QY*. Glyceraldehyde-3-phosphate Dehydrogenase Is Activated by Lysine 254 Acetylation in Response to Glucose Signal. J. Biol. Chem, 2014; 289(6):3775-85.
            14. Lv L#, Xu Y#, Zhao D, Li F, Wang W, Sasaki N, Jiang Y, Zhou X, Li T, Guan KL*, Lei QY* and Xiong Y*. Mitogenic and oncogenic stimulation of K433 acetylation promote PKM2 protein kinase activity and nuclear localization. Molecular Cell, 2013; 52:340–352. Highlights(Cover story in Molecular Cell ,Highlight by Nature Review in Cancer and Cancer Discovery)
            15. Lin R#, Ren T#, Gao X, Zhou X, Li T, Xiong Y, Guan KL, Lei QY*. Acetylation Stabilizes ATP- citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth. Molecular Cell, 2013; 51: 506–518.
            16. Zhao D#, Zou S#, Liu Y, Zhou X, Mo Y, Wang P, Xu Y, Dong B, Xiong Y*, Lei QY* and Guan KL*. Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer. Cancer Cell, 2013; 23:464-476.
            17. Lv L, Li D, Zhao D, Lin R, Chu Y,Zhang H, Zha Z, Ying Liu, Li Z, Xu Y, Huang Y, Gang W, Xiong Y, Guan KL, and Lei QY*. Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth. Molecular Cell, 2011; 42:719-730.  Feature article   Highlights (Preview in Molecular Cell, highlighs in Science Signaling, Faculty of 1000.)
             Invited Review
            1. Li JT, Wang YP, Yin M*, Lei QY*. Metabolism remodeling in pancreatic ductal adenocarcinoma. Cell Stress, 2019 Nov 4; 3(12):361-368.
            2. Wang YP*, Lei QY*. Metabolite sensing and signaling in cell metabolism. Signal Transduction and Targeted Therapy, 2018; 3:30.
            3. Zhou X, Lei QY*. Regulation of TAZ in cancer. Protein Cell, 2016; 7(8):548-61.
            4. Zhou X, Wang Z, Huang W, Lei QY*. G protein-coupled receptors: bridging the gap from the extracellular signals to the Hippo pathway. Acta Biochim Biophys Sin (Shanghai), 2015; (1):10-5.
            5. Huang W, Wang Z, Lei QY*. Acetylation control of metabolic enzymes in cancer: an updated version. Acta Biochim Biophys Sin (Shanghai), 2014; 46(3):204-13.
            6. Lin R, Zhou X, Huang W, Zhao D, Lv L, Xiong Y, Guan KL, Lei QY*.Acetylation control of cancer cell metabolism. Curr Pharm Des, 2014; 0(15):2627-33.
            7. Zhao D, Li FL, Cheng ZL, Lei QY*. Impact of acetylation on tumor metabolism. Mol Cell Oncol, 2014; 1(3):e963452. 
            8. Zhao B, Lei QY*, Guan KL*. The Hippo-YAP pathway: new connections between regulation of organ size and cancer. Current Opinion Cell Biology, 2008; 20(6):638-46.
             
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